11^th Global Experts Meeting on Chemistry And Computational Catalysis May 18-19, 2018 Holiday Inn Atrium/Singapore

Biography:

Dr. Mahesh N. Sanzgiri m.sc., phd in Organic chemistry from bombay university in 1984 under guidance of prof. V.v.nadkarny of st. Xavier’s college, mumbai. His research is dedicated to “study of few derivatives of anthrone.” &  pheromones his research work for application of  derivatives of anthrone  in anti cancer & antiaids activity is a new approach with synthesizing organic compounds using functional groups for trapping active cancer cells & removing aids activity. His work on asolating & synthesizing tigerPheromones from tiger urine and preparing same molecule in lab synthetically by usingchemical method. Its application is in  wild perfumes. With wide experience in working withmultinational german chemical & pharma co. Merck in india  for many years  onresponsible position, presently dr.mahesh sanzgiri works as a free lance scientist &Consultant  for  doing research & development, also consultant for cgmp, who, usfda, iso etc. With various well-known  indian & multinational indian & foreign companies.

Abstract:

A new series of azomethines of anthrones have been prepared by condensing anthrone with different primary amines, o-aminophenol and p-aminobenzoic acid.Similarly 10-arylidene anthrones with different functional groups were synthesized using acetic anhydrite as well as ethanol as solvent.It is found that azomethines of anthrones prepared by condensing primary amines with nitro group in p-position of aromatic ring indicate intense anticancer activity in situ as compared to other azomethines of anthrones.it is also proved that azomethin group stabilized by aromatic ring shows anticancer activity,but nitro group in p-position of aromatic ring can be considered for further investigation for development of anticancer drug, after doing detailed toxicity studies. Similarly 10-arylidene anthrones with nitro group in  p-position of aromatic ring shows antiaids activity in situ. However detailed studies of toxicity should be done before considering for further development of antiaids drugs.

Biography:

Ge Li has completed her PhD at the age of 28 years from China University of Geosciences (Beijing) She currently works at the National Institute of Clean-and-Low-Carbon Energy in China. She is a senior engineer. She has done more research on the environmental pollution of the atmosphere, water and solid waste. She has published more than 20 papers in reputed journals and applied for more than 10 Chinese invention patents.           
 

Abstract:

Fly ash emissions caused by coal combustion have been increasing for many years, causing serious environmental pollution. Coal combustion also causes large amounts of NOx to be emitted to the atmosphere, and this has caused environmental problems such as acid rain, which cannot be ignored. The denitrification catalyst V2O5/WO3-TiO2 gives a good denitrification efficiency at a high temperature but the catalyst gives a poor efficiency at low temperatures(100-300℃). Therefore, we introduce a new method based on the use of fly ash to control NOx output. We used a two-step alkali hydrothermal method to prepare SBA-15 mesoporous molecular sieves from fly ash obtained from a thermal power plant in Inner Mongolia (China). A series of bimetallic iron and manganese oxides were supported on the fly ash-derived SBA-15 catalyst and excellent NO conversion was found for NH3-SCR at low temperatures. The catalysts were characterized by: XRD; XPS; NH3-, O2-, and CO2- TPD; H2-TPR, BET analysis, SEM, TEM, and DRIFT spectroscopy. The denitration activity and denitration mechanism over the catalysts is discussed. The mechanisms of NO reduction and N2O formation over Mn/SBA-15 and Fe-Mn/SBA-15 were investigated through in situ DRIFT studies and a transient reaction study. The strong oxidation, low acidity, and high basicity of the Fe-Mn/SBA-15 catalyst contributed to a large amount of nitrate being produced during the catalysis. The nitrate decomposed to produce N2O, resulting in a decrease in N2 selectivity.  The denitration mechanism of the Fe-Mn/SBA-15 catalyst in the SCR reaction followed Langmuir-Hinshelwood, Eley-Rideal, and Mars-van Krevelen mechanisms

Biography:

Dr. Kiramat Shah is Assistant Professor at Institute of Chemical Sciences, University of Swat, Swat KPK Pakistan. He has obtained his Ph.D degree from International Center for Chemical and Biological Sciences University of Karachi, Karachi Pakistan. He is synthesizing macrocycles and macromolecules using different advanced reactions particularly Azide -Alkyne Click reaction, Glaser coupling, Sonogashira coupling, amide bond formation using coupling reagents and Mannich reaction. For the characterization of these molecules we use different techniques like 1H NMR, 13C NMR, advanced 2D NMR, EI-MS, ESI-MS, MALDI, UV-vis and FT-IR spectroscopy. To explore the chemo-sensing properties of these macrocycles and macromolecules for different antibiotics, dyes, explosives and metal ions we use UV-visible and Fluorescence spectroscopy.

Abstract:

The monitoring of pharmaceutical drugs in the environment is of great importance word wide. For instance, in 2005 six children were killed and about 200 were fill ill due to contaminated water in Karachi Pakistan. Bioassay directed chemical analysis showed that pharmaceutical drugs were present in different parts of water (drainage, surface water, and effluent) of Karachi Pakistan in highly alarming amount in the range of µg-per-liter. The use of supramolecules as optical probe for the supramolecular detection of these harmful substances in water has been recognized as very economical, selective and sensitive as compared to previously employed methodologies.

Click generated triazole based supramolecule was synthesized and characterized by 1H NMR. The supramolecular interaction of this supramolecule was explored with different antibiotics like 6APA, Aspirin, Azithromycin, Clindamycin, Fluconazole, Gentamycin, Ibuprofen, Penicillin, and Phenytoin by UV-vis spectroscopy. The study showed that click generated triazole based supramolecule selectively binds with aspirin antibiotic even in the presence of other drugs. The supramolecular interaction based developed analytical method for the detection of aspirin was validated at varying concentration, temperature and pH during recognition process. The binding stoichiometry between the click generated triazole based supramolecule and Aspirin was found to be 1:1 using Job's plot.

Biography:

Dr.Ashish Patel has honoured PhD at the age of 29 years from R.K University, one of the renowned university in Gujarat.He is the serving his professionalduty as HOD in the Dept of Pharma.Chemistry in Parul Institute of Pharmacy,Parul University.. He has published more than 16 papers in reputed journals and 3 patent on recent development of anti-T.B molecules and anti-cancer molecules and has been getting the appotunity to serving as an editorial board member of pharmaicon. He has recevied more than 10 lakh grants from various funding agency and carried out industrial consultancy for more than 2 lakh.He has awarded as best teacher for outstanding academic performance in 2013-14 as well as best academician award in 2017-18 from parul university.He has mentored & guided 16 Post graduate students of Pharma.Chemistry and Analytical Chemistry.He has published one book on The PEARSON GUIDE TO THE GPAT under Pearson publication.he is working as a associate professor with aim to provide the better education  and better platform to their students to do the researchn work for promoting the humanity and make the both  world better and they also flowrish their future.

Abstract:

mTOR, a PI3K related kinase (PIKK) family member, is a component of the mTORC1 and mTORC2 serine/threonine kinase complexes, which play key roles in cell homeostasis and growth, and are abnormally regulated in tumor cells. Aberrant activation of the PI3K signalling cascade stimulates cell growth, survival, proliferation, and migration. More than 50% of all solid tumors have gene mutations, deletions, or amplifications that lead to upregulated PI3K/mTOR signalling. Therefore, blocking the mTOR signalling pathway by inhibiting mTOR serine/threonine kinase activity provides an innovative strategy for cancer therapy. Benzothiazole derivatives were docked against our target m-TOR retrieved from our Protein Data Bank (PDB Id: 3Qk0). Docking results revealed that, with respect to their free binding energy RB1, RB2, RB3, RB9, RB17 and RB19 compounds have highest binding energy by interaction with Try876, Asp964, ASN951, ILE831 aminoacid residues. The designed molecules showed better binding affinity in terms of estimated docking scores with respect to the already reported system; hence suggesting that newly designed molecules may serve as potential lead compound for developing new m-TOR inhibitors.

Key Words:- m-TOR, PI3K, Benzothiazole

Biography:

Dr.Ishan Panchal has honoured PhD at the age of 31 years from Gujarat Technological University, one of the renowned university in Gujarat.He is the serving his professionalduty as assistant professor, Dept of Pharma.Chemistry in Parul Institute of Pharmacy,Parul University.. He has published more than 19 papers in reputed journals.He has mentored & guided 6 Post graduate students of Pharma.Chemistry and Analytical Chemistry.He has published two monograph in  lambert acadmic publishing house book on The.he is working as a associate professor with aim to inculcate  the subjective knowledge and also to improve the behavior to compete with the world  to brighten their future as will as to serve their duties to make the both of the world better.

Abstract:

Objective: The present work deals with the design, synthesis, characterization of novel substituted 2-(4-phenylamino)-N-(5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-yl)acetamide (RRC 5a-5e) and substituted N-(5-(phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-(phenylamino)acetamide(RRC 5f-5i) derivatives as small lung cancer.  

Methods: Novel 1, 3, 4 Oxadiazole derivatives were synthesized and characterized by melting point, TLC, IR Spectroscopy, Mass spectroscopy and ¹H NMR. In vitro biological evaluation was performed on NCI-H2066 cell line for  different concentrations 10-1000µM by telomeric repeat amplification protocol assay.  

Results: Novel substituted 2-(4-phenylamino)-N-(5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-yl)acetamide (RRC 5a-5e) and substituted N-(5-(phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-(phenylamino)acetamide(RRC 5f-5i) were synthesized, and characterized using spectral and analytical data. All compounds have shown considerable % inhibition of Cell Growth with respect to Bevacizumab, but compound RRC 5a and RRC 5f are equipotent with respect to activity as compared to standard Bevacizumab. IC50 value of RRC 5a and RRC 5f are 33.05μM and 35.58μM concentration respectively.  

Conclusion: Among the hybrids, p-Nitro substituted derivative (RRC 5a) and p-Chloro substituted (RRC 5f) showed highest activity against human lung cancer cell line NCI-H2066 by TRAP assay.  

Key Words: Oxadiazole, NCI-H2066, cell line, TRAP assay

Biography:

We will update soon.

Abstract:

The Arachis hypogeal seed shell which a by product from Groundnuts was envisigated as an organic fertiliser characterising its physico--chemical characteristic properties as well as chemical composition. Arachis hypogeal L(groundnuts) seed shell Ash were evaluated by different techniques such as X-ray flourences, X-ray diffraction and thermgravimetric analysis. The analysis was done inorder to determine its suitability as organic fertilizer, source of energy and as animal feed. This will provide a reasonable economic means for this waste product in an environmentally friendly manner. The result of X-ray flourences of the Arachis hypogeal L ash haven shown a high percentage of macro_elements such as Ca, Zn Mg and Cl. Also micro elements such as Cr. Thermogravimetry result indicated massive destruction organic matter leading to low ash content, which indicate its suitability as an energy source. Green house experiment was conducted on radish plant with application of the ash as a control. The yiel and yield parameters indicated high performance of the ash when applied to the plants as a fertilised in an irish mosepeat medium.

Biography:

We will update soon.

Abstract:

The research area was in Gashua, Bade Local Government Area, Yobe State, Nigeria. The levels of fluoride, cadmium, arsenic, lead, iron and nickel were determined in sachet and borehole water samples. The levels of fluoride, cadmium, arsenic, lead, iron and nickel were also determined in blood and urine samples with respect to age groups and gender. Sample collection and preparations were carried out using standard procedures. The concentrations of all the studied metals were determined using atomic absorption spectroscopy (A.A.S). The concentration of fluoride was observed to be higher in the male subjects when compared to the female subjects. It was also observed that the concentration of fluoride was significantly higher in the urine samples when compared to the blood samples. From the present study the concentration of iron ranged from 0.11 to 2.13 mg/L, 0.01 to 1.42 mg/L arsenic, 0.01 to 2.13 mg/L cadmium, 0.01 to 1.77 mg/L nickel and   0.02 to 2.13 mg/L lead. Results from the present study showed that the mean concentrations of arsenic in the borehole water samples from the different wards in Gashua ranged from 0.87 to 2.98 mg/L; 0.44 to 0.77 mg/L lead, 1.04 to 2.13 mg/L nickel, 0.12 to 0.35 mg/L cadmium and 2.56 to 5.56 mg/L iron. The values obtained from the borehole water samples were higher than the WHO standard value of 0.05 mg/L arsenic, 1.0 mg/L iron, 0.01 mg/L lead, 0.07 mg/L nickel and 0.005 mg/L cadmium for drinking water. Information from this research showed the possible factors that may result in gender metal accumulation. The concentrations of all the study metals in the urine and blood samples were significantly higher than the WHO limits. Data obtained from borehole water samples showed that, the borehole water might be a contributing factor to blood/urine metal accumulation. Information from this research also showed the possible factors that may result to higher concentrations of all the metals in urine (both recent and past exposure) when compared to blood (only recent exposure). Data obtained from the present research indicate that the concentrations of all the metals in the blood and urine samples increased with increase in age group. This fact could be explained by the tendency of heavy metals to accumulate in the human body (bioaccumulation of heavy metals) with time, indicating that metal accumulation is age dependent.