11th Global Experts Meeting on Chemistry And Computational Catalysis
Singapore City, singapore
Institute Of Chemical Science University Of Swat, Pakistan
Title: Synthesis and Characterization of triazole based supramolecule and its Supramolecular detection of Asprin in water and human blood plasma.
Biography: Kiramat Shah
The monitoring of pharmaceutical drugs in the environment is of great importance word wide. For instance, in 2005 six children were killed and about 200 were fill ill due to contaminated water in Karachi Pakistan. Bioassay directed chemical analysis showed that pharmaceutical drugs were present in different parts of water (drainage, surface water, and effluent) of Karachi Pakistan in highly alarming amount in the range of µg-per-liter. The use of supramolecules as optical probe for the supramolecular detection of these harmful substances in water has been recognized as very economical, selective and sensitive as compared to previously employed methodologies.
Click generated triazole based supramolecule was synthesized and characterized by 1H NMR. The supramolecular interaction of this supramolecule was explored with different antibiotics like 6APA, Aspirin, Azithromycin, Clindamycin, Fluconazole, Gentamycin, Ibuprofen, Penicillin, and Phenytoin by UV-vis spectroscopy. The study showed that click generated triazole based supramolecule selectively binds with aspirin antibiotic even in the presence of other drugs. The supramolecular interaction based developed analytical method for the detection of aspirin was validated at varying concentration, temperature and pH during recognition process. The binding stoichiometry between the click generated triazole based supramolecule and Aspirin was found to be 1:1 using Job's plot.