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11th Global Experts Meeting on Chemistry And Computational Catalysis

Singapore City, singapore

Pinkal Patel

Pinkal Patel

Parul University, India

Title: Synthesis and Pharmacological Evaluation Of Pyrazole Derivatives


Biography: Pinkal Patel


The pyrazole ring is an important structural moiety found in numerous pharmaceutically active compounds. This is mainly due to the ease preparation and the important versatile biological activity. When pyrazoles were discovered, they were mostly useful as a anti-nflamatory and analgesic but in recent times, they are known to exhibit antibacterial and several other pharmacological actions like antifungal, anti inflammatory, analgesic, antipyretic, insecticides, herbicide and also used as dyestuffs in sunscreen materials and as analytical reagents. The present study involves synthesis of substituted  pyrazole derivatives as an antiinflamatory activity. From the literature survey carried out it was planned to synthesize substituted 1,5-dipehnyl-1H-pyrazole-3-carboxylic acid PDG 1.3(a-d)  and PDG 2.3(a-d)  as antiinflamatory agent. Substituted pyrazole were synthesized by cyclocondensation reaction. . The structure activity relationship of the pyrazole ring suggests that presence of bulky group on the 1st and 5th position increase selectivity and increase polarity on the 3rd position enhances anti-inflammatory activity. The pyrazole containing compounds were synthesized according to synthetic scheme. The synthesis of compounds were confirmed by TLC, IR, NMR and Mass spectroscopy. The synthesized compounds were screened for anti-inflammatory & analgesic activity. The Compound PDG 1.3c was found to be most active among the series