Mahesh N. Sanzgiri
St. Xaviers college, India.
Title: Synthesis Of Azomethines Of Anthrones And 10- Arylidene Anthrones And Testing For Anticancer And Antiaids Activity.
Biography
Biography: Mahesh N. Sanzgiri
Abstract
A new series of azomethines of anthrones have been prepared by condensing anthrone with different primary amines, o-aminophenol and p-aminobenzoic acid.Similarly 10-arylidene anthrones with different functional groups were synthesized using acetic anhydrite as well as ethanol as solvent.It is found that azomethines of anthrones prepared by condensing primary amines with nitro group in p-position of aromatic ring indicate intense anticancer activity in situ as compared to other azomethines of anthrones.it is also proved that azomethin group stabilized by aromatic ring shows anticancer activity,but nitro group in p-position of aromatic ring can be considered for further investigation for development of anticancer drug, after doing detailed toxicity studies. Similarly 10-arylidene anthrones with nitro group in p-position of aromatic ring shows antiaids activity in situ. However detailed studies of toxicity should be done before considering for further development of antiaids drugs.