Atcahree Ratwatthananon
Kasetsart University, Thailand
Title: Synthesis and acetylcholinesterase inhibitory activity of piperate ester
Biography
Biography: Atcahree Ratwatthananon
Abstract
Piperine is a major alkaloid component of Piper retrofractum fruits, has been reported as an acetylcholinesterase inhibitor.In this study, a series of piperate esters were evaluated the acetylcholinesterase inhibitory activity comparing with piperine using modified Ellman method. These compounds were designed and synthesized from piperine, isolated from P. Retrofractum, by hydrolysis into piperic acid followed esterification with various alcohols to produce the corresponding esters in low to high yields. The results found that menthyl piperate showed acetylcholinesterase inhibitory activity in higher than piperine and the other piperate esters.