Meet Inspiring Speakers and Experts at our 3000+ Global Conference Series LLC LTD Events with over 1000+ Conferences, 1000+ Symposiums
and 1000+ Workshops on Medical, Pharma, Engineering, Science, Technology and Business.

Explore and learn more about Conference Series LLC LTD : World’s leading Event Organizer

Back

11th Global Experts Meeting on Chemistry And Computational Catalysis

Singapore City, singapore

Adiel Coca

Adiel Coca

Professor, Southern Connecticut State University USA

Title: Preparation and Antimicrobial Properties of Tetrazole Derivatives

Biography

Biography: Adiel Coca

Abstract

The tetrazole ring has been featured in several approved anti-hypertension drugs such as losartan, olmesartan, irbesartan, valsartan, candesartan and fimasartan. Tetrazole derivatives have also been used as lipophilic spacers, peptide chelating agents, and as cis-peptide bond mimics. Perhaps the most common application of the tetrazole ring is as a bioisotere for carboxylic acids due to similar acidity and planarity. The tetrazole ring is typically synthesized via the (3+2) cycloaddition of an organonitrile and sodium azide in aprotic polar solvents such as dimethylformamide. In this work, several tetrazole derivatives were synthesized in good yields using a rare-earth metal catalyst. Microwave radiation was used to heat the reactions which were done in an aqueous solvent mixture. The antimicrobial properties of the resulting tetrazole derivatives were determined against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa. Some tetrazole derivatives showed a significant synergistic effect when used in combination with trimethoprim