11^th Global Experts Meeting on Chemistry And Computational Catalysis May 18-19, 2018 Holiday Inn Atrium/Singapore

Biography:

Dr. Abdeen Mustafa Omer (BSc, MSc, PhD) is an Associate Researcher at Energy Research Institute (ERI). He obtained both his PhD degree in the Built Environment and Master of Philosophy degree in Renewable Energy Technologies from the University of Nottingham. He is qualified Mechanical Engineer with a proven track record within the water industry and renewable energy technologies. He has been graduated from University of El Menoufia, Egypt, BSc in Mechanical Engineering. His previous experience involved being a member of the research team at the National Council for Research/Energy Research Institute in Sudan and working director of research and development for National Water Equipment Manufacturing Co. Ltd., Sudan. He has been listed in the book WHO’S WHO in the World 2005, 2006, 2007 and 2010. He has published over 300 papers in peer-reviewed journals, 200 review articles, 7 books and 150 chapters in books.

Abstract:

Sudan's climatic conditions (mainly the rainy seasons) enable double annual harvests (in July and November) in the southern parts of the country. Most of the agricultural activities are concentrated near the Nile River. The El Gezira irrigation system that is located between the White and the Blue Nile Rivers (both rivers merge to form the Nile River) is the most important agriculture project and, according to some statistics, is also the largest artificially irrigated region in the world. As the irrigation system has been put in place, sorghum, wheat, and groundnuts have been planted instead of cotton in an effort to make Sudan self-sufficient in foodstuffs. The agricultural sector is the most important economic sector in Sudan. It created 39 percent of the gross domestic production (GDP), employed about 80 percent of population, and contributed 80 percent of the country's exports in the late 1990s. Cotton is the main agriculture export item, although its export volumes have been decreasing recently. The lack of any marketing or developed market policy is evident. The government has suggested the end of export taxes in order to promote more agriculture products in the future. Other agricultural products include sesame seeds, sorghum, and gum Arabic. Animal husbandry represents a very important part of the national economy, as well. Its production increased during recent years as a result of better veterinary treatment, better credit policy, and higher prices in the market. Fishing is another important sector of the national economy. The average yearly production averages around 33,000 tons, from which sea fish represent about 1,500 tons. Perch is the most important fresh-water fish, which is caught mostly in the Nile River. About one-third of the total area of Africa's largest country is suitable for agricultural development. Abundant rainfall in the south permits both agriculture and grazing grounds for the large herds owned by nomadic tribes. In the north, along the banks of the Nile and other rivers, irrigation farming prevails. Of an estimated 16.9 million hectares (41.8 million acres) of arable landing 1998, about 1.9 million hectares (4.7 million acres) were irrigated. Principal cash crops are cotton, sesame, peanuts, sugarcane, dates, citrus fruits, mangoes, coffee, and tobacco; the principal subsistence crops are sorghum, millet, wheat, beans, cowpeas, pulses, corn, and barley. Cotton is the principal export crop and an integral part of the country's economy. In 2001, agricultural products accounted for 21.9% of imports and 19.2% of exports; there was an agricultural trade deficit of $24.5 million. Government regional development schemes have played a decisive part in the economy since the 1920s. The Gezira Scheme, located between the Blue and White Niles near their confluence at Khartoum, is the world's largest under a single management and provides a substantial portion of foreign exchange and government revenue. This storage irrigation project, which covers 840,000 hectares (more than two million acres) but has an additional potential of two million hectares (5 million acres), dates back to 1911 and was put into operation by a British firm. After the expiration of the firm's contract with the Sudanese government in 1950, the land was leased to tenant farmers, who numbered over 100,000 in 1987. They manage the scheme jointly with the government through the Gezira Board. In July 1980, construction began on the 354-km (220-mile) Jonglei Canal, intended to drain the Sudd swamp and channel water from the White Nile to the arid northern Sudan and to Egypt. Built by a French consortium at a projected cost of $260 million and scheduled for completion in 1985, the canal could irrigate up to 243,000 ha (600,000 acres) of Sudanese land. By 1984, however, the project had been halted by the Sudanese People’s Liberation Army (SPLA) opposition, with less than 100 km (62 mi) to be excavated. In 1992, the public and private agricultural sectors invested heavily in land preparations, pesticides, and related inputs. Agricultural funding for such projects comes from the World Bank, the African Development Bank, and the International Fund for Agricultural Development. However, completion of these projects has been complicated by debt-repayment problems. In spite of efforts to improve Sudan's agricultural resources, famine conditions have existed in southern Sudan since 1986. Inadequate rains, a poor distribution infrastructure, and civil war have hampered relief efforts. Among agricultural products in 1999 were sorghum, 3,045,000 tons; peanuts, 980,000 tons; sesame, 220,000 tons, (the third highest in the world after India and China); and wheat, 168,000 tons. Cotton fibre production in 1999 was 172,000 tons. Production in 1999 also included sugarcane, 5,950,000 tons; millet, 1,499,000 tons; cottonseed, 131,000 tons; tomatoes, 240,000 tons; dates, 176,000 tons; yams, 136,000 tons; and corn, 65,000 tons 

Biography:

Will be Updated Soon.

Abstract:

The research area was in Gashua, Bade Local Government Area, Yobe State, Nigeria. The levels of fluoride, cadmium, arsenic, lead, iron and nickel were determined in sachet and borehole water samples. The levels of fluoride, cadmium, arsenic, lead, iron and nickel were also determined in blood and urine samples with respect to age groups and gender. Sample collection and preparations were carried out using standard procedures. The concentrations of all the studied metals were determined using atomic absorption spectroscopy (A.A.S). The concentration of fluoride was observed to be higher in the male subjects when compared to the female subjects. It was also observed that the concentration of fluoride was significantly higher in the urine samples when compared to the blood samples. From the present study the concentration of iron ranged from 0.11 to 2.13 mg/L, 0.01 to 1.42 mg/L arsenic, 0.01 to 2.13 mg/L cadmium, 0.01 to 1.77 mg/L nickel and   0.02 to 2.13 mg/L lead. Results from the present study showed that the mean concentrations of arsenic in the borehole water samples from the different wards in Gashua ranged from 0.87 to 2.98 mg/L; 0.44 to 0.77 mg/L lead, 1.04 to 2.13 mg/L nickel, 0.12 to 0.35 mg/L cadmium and 2.56 to 5.56 mg/L iron. The values obtained from the borehole water samples were higher than the WHO standard value of 0.05 mg/L arsenic, 1.0 mg/L iron, 0.01 mg/L lead, 0.07 mg/L nickel and 0.005 mg/L cadmium for drinking water. Information from this research showed the possible factors that may result in gender metal accumulation. The concentrations of all the study metals in the urine and blood samples were significantly higher than the WHO limits. Data obtained from borehole water samples showed that, the borehole water might be a contributing factor to blood/urine metal accumulation. Information from this research also showed the possible factors that may result to higher concentrations of all the metals in urine (both recent and past exposure) when compared to blood (only recent exposure). Data obtained from the present research indicate that the concentrations of all the metals in the blood and urine samples increased with increase in age group. This fact could be explained by the tendency of heavy metals to accumulate in the human body (bioaccumulation of heavy metals) with time, indicating that metal accumulation is age dependent.

Biography:

Will be updated soon.

Abstract:

Soil samples in abandon gold mine of Dutse-Maru of Maru local government area of Zamfara state were collected and analyzed with the use of energy dispersive x-ray arrangement to determine the level of heavy metals concentration contained. The choice of Dutse-Maru abandon mine for analytical assessment was informed by the strategic drainage pattern of the site in relation to the Sokoto river which it empty into. The presence of elevated heavy metals in the site can be of health implications to the users of the river. The major elements in the samples were found to be Fe, Mn ,Cu, K and Ca. The range of concentrations of these elements in the stated order are;28270-315366ppm, 582-4462ppm, 645-20506ppm, 51193-56395ppm and14879-39528ppm.The element that occurs in trace proportion relative to these stated ones in the accessed samples are Mn, Ti, and Zn. It can be observed that Fe occurrence in raised proportion at many folds above permissible level is a potential treat to users of the river at its lower end. However an overall observation reveals that there is no immediate health risk signals from the preliminary results so obtained.  

Biography:

Dr. Mahesh N. Sanzgiri m.sc., phd in Organic chemistry from bombay university in 1984 under guidance of prof. V.v.nadkarny of st. Xavier’s college, mumbai. His research is dedicated to “study of few derivatives of anthrone.” &  pheromones his research work for application of  derivatives of anthrone  in anti cancer & antiaids activity is a new approach with synthesizing organic compounds using functional groups for trapping active cancer cells & removing aids activity. His work on asolating & synthesizing tigerPheromones from tiger urine and preparing same molecule in lab synthetically by usingchemical method. Its application is in  wild perfumes. With wide experience in working withmultinational german chemical & pharma co. Merck in india  for many years  onresponsible position, presently dr.mahesh sanzgiri works as a free lance scientist &Consultant  for  doing research & development, also consultant for cgmp, who, usfda, iso etc. With various well-known  indian & multinational indian & foreign companies.

Abstract:

A new series of azomethines of anthrones have been prepared by condensing anthrone with different primary amines, o-aminophenol and p-aminobenzoic acid.Similarly 10-arylidene anthrones with different functional groups were synthesized using acetic anhydrite as well as ethanol as solvent.It is found that azomethines of anthrones prepared by condensing primary amines with nitro group in p-position of aromatic ring indicate intense anticancer activity in situ as compared to other azomethines of anthrones.it is also proved that azomethin group stabilized by aromatic ring shows anticancer activity,but nitro group in p-position of aromatic ring can be considered for further investigation for development of anticancer drug, after doing detailed toxicity studies. Similarly 10-arylidene anthrones with nitro group in  p-position of aromatic ring shows antiaids activity in situ. However detailed studies of toxicity should be done before considering for further development of antiaids drugs.

Biography:

Ge Li has completed her PhD at the age of 28 years from China University of Geosciences (Beijing) She currently works at the National Institute of Clean-and-Low-Carbon Energy in China. She is a senior engineer. She has done more research on the environmental pollution of the atmosphere, water and solid waste. She has published more than 20 papers in reputed journals and applied for more than 10 Chinese invention patents.           
 

Abstract:

Fly ash emissions caused by coal combustion have been increasing for many years, causing serious environmental pollution. Coal combustion also causes large amounts of NOx to be emitted to the atmosphere, and this has caused environmental problems such as acid rain, which cannot be ignored. The denitrification catalyst V2O5/WO3-TiO2 gives a good denitrification efficiency at a high temperature but the catalyst gives a poor efficiency at low temperatures(100-300℃). Therefore, we introduce a new method based on the use of fly ash to control NOx output. We used a two-step alkali hydrothermal method to prepare SBA-15 mesoporous molecular sieves from fly ash obtained from a thermal power plant in Inner Mongolia (China). A series of bimetallic iron and manganese oxides were supported on the fly ash-derived SBA-15 catalyst and excellent NO conversion was found for NH3-SCR at low temperatures. The catalysts were characterized by: XRD; XPS; NH3-, O2-, and CO2- TPD; H2-TPR, BET analysis, SEM, TEM, and DRIFT spectroscopy. The denitration activity and denitration mechanism over the catalysts is discussed. The mechanisms of NO reduction and N2O formation over Mn/SBA-15 and Fe-Mn/SBA-15 were investigated through in situ DRIFT studies and a transient reaction study. The strong oxidation, low acidity, and high basicity of the Fe-Mn/SBA-15 catalyst contributed to a large amount of nitrate being produced during the catalysis. The nitrate decomposed to produce N2O, resulting in a decrease in N2 selectivity.  The denitration mechanism of the Fe-Mn/SBA-15 catalyst in the SCR reaction followed Langmuir-Hinshelwood, Eley-Rideal, and Mars-van Krevelen mechanisms

Biography:

Dr. Kiramat Shah is Assistant Professor at Institute of Chemical Sciences, University of Swat, Swat KPK Pakistan. He has obtained his Ph.D degree from International Center for Chemical and Biological Sciences University of Karachi, Karachi Pakistan. He is synthesizing macrocycles and macromolecules using different advanced reactions particularly Azide -Alkyne Click reaction, Glaser coupling, Sonogashira coupling, amide bond formation using coupling reagents and Mannich reaction. For the characterization of these molecules we use different techniques like 1H NMR, 13C NMR, advanced 2D NMR, EI-MS, ESI-MS, MALDI, UV-vis and FT-IR spectroscopy. To explore the chemo-sensing properties of these macrocycles and macromolecules for different antibiotics, dyes, explosives and metal ions we use UV-visible and Fluorescence spectroscopy.

Abstract:

The monitoring of pharmaceutical drugs in the environment is of great importance word wide. For instance, in 2005 six children were killed and about 200 were fill ill due to contaminated water in Karachi Pakistan. Bioassay directed chemical analysis showed that pharmaceutical drugs were present in different parts of water (drainage, surface water, and effluent) of Karachi Pakistan in highly alarming amount in the range of µg-per-liter. The use of supramolecules as optical probe for the supramolecular detection of these harmful substances in water has been recognized as very economical, selective and sensitive as compared to previously employed methodologies.

Click generated triazole based supramolecule was synthesized and characterized by 1H NMR. The supramolecular interaction of this supramolecule was explored with different antibiotics like 6APA, Aspirin, Azithromycin, Clindamycin, Fluconazole, Gentamycin, Ibuprofen, Penicillin, and Phenytoin by UV-vis spectroscopy. The study showed that click generated triazole based supramolecule selectively binds with aspirin antibiotic even in the presence of other drugs. The supramolecular interaction based developed analytical method for the detection of aspirin was validated at varying concentration, temperature and pH during recognition process. The binding stoichiometry between the click generated triazole based supramolecule and Aspirin was found to be 1:1 using Job's plot.

Biography:

Dr.Ashish Patel has honoured PhD at the age of 29 years from R.K University, one of the renowned university in Gujarat.He is the serving his professionalduty as HOD in the Dept of Pharma.Chemistry in Parul Institute of Pharmacy,Parul University.. He has published more than 16 papers in reputed journals and 3 patent on recent development of anti-T.B molecules and anti-cancer molecules and has been getting the appotunity to serving as an editorial board member of pharmaicon. He has recevied more than 10 lakh grants from various funding agency and carried out industrial consultancy for more than 2 lakh.He has awarded as best teacher for outstanding academic performance in 2013-14 as well as best academician award in 2017-18 from parul university.He has mentored & guided 16 Post graduate students of Pharma.Chemistry and Analytical Chemistry.He has published one book on The PEARSON GUIDE TO THE GPAT under Pearson publication.he is working as a associate professor with aim to provide the better education  and better platform to their students to do the researchn work for promoting the humanity and make the both  world better and they also flowrish their future.

Abstract:

mTOR, a PI3K related kinase (PIKK) family member, is a component of the mTORC1 and mTORC2 serine/threonine kinase complexes, which play key roles in cell homeostasis and growth, and are abnormally regulated in tumor cells. Aberrant activation of the PI3K signalling cascade stimulates cell growth, survival, proliferation, and migration. More than 50% of all solid tumors have gene mutations, deletions, or amplifications that lead to upregulated PI3K/mTOR signalling. Therefore, blocking the mTOR signalling pathway by inhibiting mTOR serine/threonine kinase activity provides an innovative strategy for cancer therapy. Benzothiazole derivatives were docked against our target m-TOR retrieved from our Protein Data Bank (PDB Id: 3Qk0). Docking results revealed that, with respect to their free binding energy RB1, RB2, RB3, RB9, RB17 and RB19 compounds have highest binding energy by interaction with Try876, Asp964, ASN951, ILE831 aminoacid residues. The designed molecules showed better binding affinity in terms of estimated docking scores with respect to the already reported system; hence suggesting that newly designed molecules may serve as potential lead compound for developing new m-TOR inhibitors.

Key Words:- m-TOR, PI3K, Benzothiazole

Biography:

Dr.Ishan Panchal has honoured PhD at the age of 31 years from Gujarat Technological University, one of the renowned university in Gujarat.He is the serving his professionalduty as assistant professor, Dept of Pharma.Chemistry in Parul Institute of Pharmacy,Parul University.. He has published more than 19 papers in reputed journals.He has mentored & guided 6 Post graduate students of Pharma.Chemistry and Analytical Chemistry.He has published two monograph in  lambert acadmic publishing house book on The.he is working as a associate professor with aim to inculcate  the subjective knowledge and also to improve the behavior to compete with the world  to brighten their future as will as to serve their duties to make the both of the world better.

Abstract:

Objective: The present work deals with the design, synthesis, characterization of novel substituted 2-(4-phenylamino)-N-(5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-yl)acetamide (RRC 5a-5e) and substituted N-(5-(phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-(phenylamino)acetamide(RRC 5f-5i) derivatives as small lung cancer.  

Methods: Novel 1, 3, 4 Oxadiazole derivatives were synthesized and characterized by melting point, TLC, IR Spectroscopy, Mass spectroscopy and ¹H NMR. In vitro biological evaluation was performed on NCI-H2066 cell line for  different concentrations 10-1000µM by telomeric repeat amplification protocol assay.  

Results: Novel substituted 2-(4-phenylamino)-N-(5-((4-nitrophenoxy)methyl)-1,3,4-oxadiazol-2-yl)acetamide (RRC 5a-5e) and substituted N-(5-(phenoxymethyl)-1,3,4-oxadiazol-2-yl)-2-(phenylamino)acetamide(RRC 5f-5i) were synthesized, and characterized using spectral and analytical data. All compounds have shown considerable % inhibition of Cell Growth with respect to Bevacizumab, but compound RRC 5a and RRC 5f are equipotent with respect to activity as compared to standard Bevacizumab. IC50 value of RRC 5a and RRC 5f are 33.05μM and 35.58μM concentration respectively.  

Conclusion: Among the hybrids, p-Nitro substituted derivative (RRC 5a) and p-Chloro substituted (RRC 5f) showed highest activity against human lung cancer cell line NCI-H2066 by TRAP assay.  

Key Words: Oxadiazole, NCI-H2066, cell line, TRAP assay

Biography:

Author presently working in Parul institute of pharmacy As a asst.professor, I have total 8 years of experience in various field .I worked in IPR division in Delhi specially for patent,Apart from this I am pursuing PHD. I have life time membership for APTI,I am a registered pharmacist. during the post graduation degree I received the scholarship from AICTE,Delhi ,I also did MBA and served  as a administrator in reputated organisation, with aim to provide better facility to the student so they fulfils their dream and make the world better place for humanity

Abstract:

Diabetes mellitus is a major affective disorder, common in the general population. Worldwide there is a renewed interest in the development of an effective medicine against the most dreaded diseases. Earlier known the class of Phenyl substituted carboxylic acids and Benzamide Derivatives are found to be good candidate for inhibitors of various PTPs, especially as PTP-1B. In the present study we propose to develop a new substituted 4-Carboxy Benzamide derivative, these can be prepared and can be checked for antidiabetic activity. The experimental work has been divided into two main parts: 1.Synthesis Work   2. Biological Studies, Therefore which prove the Inhibition of PTPase and Activation of insulin receptor and downstream functions could provide new therapeutic strategy for diabetes mellitus. 

Biography:

Dr. Pinkal Patel has completed her Ph.D. from Jodhpur National University and M. Pharm in medicinal chemistry from  M.S. University, Vadodara, one of the renowned university in Gujarat. She is the serving his professional duty as HOD in the Dept of Pharma. Chemistry in Parul Institute of Pharmacy and research, Parul University. She has published more than 15 papers in reputed journals and presented more than 12 papers in various conferences.  She has been getting the opportunity to serve as an editorial board member of pharmacy. She was awarded as best teacher for outstanding academic performance in 2013-14 from Parul university. She has mentored & guided 29 Postgraduate students of Pharma. Analytical Chemistry. she is having 13 years teaching experience and working as an associate professor with the aim to provide the better education and better platform to their students to do the research work for promoting the human and make the world better.

Abstract:

The pyrazole ring is an important structural moiety found in numerous pharmaceutically active compounds. This is mainly due to the ease preparation and the important versatile biological activity. When pyrazoles were discovered, they were mostly useful as a anti-nflamatory and analgesic but in recent times, they are known to exhibit antibacterial and several other pharmacological actions like antifungal, anti inflammatory, analgesic, antipyretic, insecticides, herbicide and also used as dyestuffs in sunscreen materials and as analytical reagents. The present study involves synthesis of substituted  pyrazole derivatives as an antiinflamatory activity. From the literature survey carried out it was planned to synthesize substituted 1,5-dipehnyl-1H-pyrazole-3-carboxylic acid PDG 1.3(a-d)  and PDG 2.3(a-d)  as antiinflamatory agent. Substituted pyrazole were synthesized by cyclocondensation reaction. . The structure activity relationship of the pyrazole ring suggests that presence of bulky group on the 1^st and 5^th position increase selectivity and increase polarity on the 3^rd position enhances anti-inflammatory activity. The pyrazole containing compounds were synthesized according to synthetic scheme. The synthesis of compounds were confirmed by TLC, IR, NMR and Mass spectroscopy. The synthesized compounds were screened for anti-inflammatory & analgesic activity. The Compound PDG 1.3c was found to be most active among the series

Biography:

I am Prof.Dr.Prakash.M.M.S Kinthada, a Professor in the Department Of Chemistry at Sri Vidyanikethan Engineering college,Jawahar Lal Technological University,Anantapur,A.Rangam Peta, Tirupathi,INDIA.Earlier I was an AssociateProfessor in Chemistry ,GIT,GITAM University, Visakhapatnam, INDIA. Ihave recently returned from USA, where I was a NIH visiting fellow atKARMONAS CANCER RESEARCHINSTITUTE, Wayne State University School OfMedicine. Earlier I was a Royal Society Visiting Scientist in theInorganic chemistry laboratories at the University of Oxford,UK, working on" Transition metal complexes as Anticancer Drugs".Earlier I was a visiting fellow at the Department of ChemicalEngineering and Applied Chemistry at Aston University, Birmingham.Prior to that I was a Nehru Centenary British Council Fellow in theorganometallic laboratories at Imperial college of Science, Technologyand Medicine, London, UK. Prior to that I was a CSIR Researchassociate in the Organometallic laboratories, Department of chemistry,INDIAN INSTITUTE OF  TECHNOLOGY,NEWDELHI,INDIA. I have published allmy research in high impact international journals and Presented papersin International Conferences including American Chemical societyConferences.I have published 33 International publications and 31international conference presentations including American ChemicalSociety conferences.

Abstract:

Cancer is a dreadful disease and any practical solution in combating this disease is of paramount importance to public health. Cancer patients have burdened by drug induced toxic side effects, and no turned to seek help from the complementary and alternative medicine hoping for a better cure. Research on Platinum based drugs and Non Platinum based drugs is a Multi-Million Dollar Industry in USA and there is every need to produce safe drugs for the cure of this monstrous disease. Flavonoids have a long history of use in traditional medicines in many cultures. The phytochemical, curcumin is one of the major dietary flavonoid, belonging to a group of flavonol, Curcumin is a natural polyphenol. It is highly potential molecule capable of preventing and treating various cancers.  Various dietary chemo preventive agents, turmeric powder or its extract are broadly used as therapeutic preparations in Indian System of medicine. We provide a summarized synthesis and structural determination of Curcumin Oxime, Curcumin Thiosemicarbazone derivative of Gold (III) complex. The use of these analogs for prevention of cancer tumor progression and treatments of human malignancies. A pharmacologic agent for treating and/or preventing cancer, among other diseases and conditions, and particularly breast, prostate, and pancreatic cancer, in humans and animals. The novel pharmacologic agent is an isoflavonoid or isoflavonoid mimetic covalently attached to a cytotoxic pharmacophore that, preferably has the ability to conjugate with a metal salt to form a more potent metal complex, particularly a Au (III) complex and other complexes of Platinum, Palladium, Ruthenium, Copper etc.

My talk would mainly encompass different Transition Metal Complexes/Organometallic Compounds   that are presently used as drugs, especially Anticancer and Anti-HIV drugs, apart from Anti-inflammatory, Antimicrobial, Antibacterial and diseases like Arthritis and Parkinson’s Disease etc. The talk would mainly focus on the use of Medicinal Chemistry and it’s application to Drug Design and Development in Pharmaceutical Industry ,  especially    Transition Metal Complexes and Organometallic Compounds viz. Gold, Platinum, Palladium And Ruthenium apart from Copper, Cobalt, Iron,  Nickel, Zinc, Cadmium etc.

The main emphasis of my talk would be on Different class of Ligands, their Schiff’s Bases and Transition Metal Complexes especially Au, Pt, Pd and Ru, with the main aim of designing, developing very novel small molecules, as possible and extremely potential candidates as Anti-cancer and Anti-HIV drugs. The talk would provide an overview of current programs being undertaken in our laboratories, especially focused on the development of potent ligands capable of recognizing Binding sites and diverse strategies employed by my group for elucidation of Anti-Cancer and Anti-HIV drug Leads to Circumvent the problem caused by Cis-Platin.

We have synthesized and characterized several phytochemicals from Traditional Medicinal Plants and isolated some phytochemicals and  made the corresponding Oximes, Thiosemicarbazones and Substituted thiosemicarbazones as ligands and synthesized, characterized, structurally elucidated their Transition Metal Complexes especially with Gold, Platinum, Palladium, Ruthenium, Copper etc. and Studied their Anticancer Activity, Nuclease activity etc. and tested their potential as Anticancer Drugs.

The main aim of our extensive/preclinical Pharmaceutical development program is to investigate the use of these extremely novel small molecules-metal complexes/compounds of phytochemicals, flavanoids etc., which have very interesting structural features and properties and hence are excellent candidates as Anti-Cancer and Anti-HIV drugs .The main aim of our research is Design ,Development and Synthesis of Transition Metal Complexes/ Organometallic Compounds that would certainly help to bring this force of nature from BENCH to BEDSIDE and enhance Cancer Killing with less toxic effects and would certainly lead to initiation of clinical trials.

Biography:

We will update soon.

Abstract:

The Arachis hypogeal seed shell which a by product from Groundnuts was envisigated as an organic fertiliser characterising its physico--chemical characteristic properties as well as chemical composition. Arachis hypogeal L(groundnuts) seed shell Ash were evaluated by different techniques such as X-ray flourences, X-ray diffraction and thermgravimetric analysis. The analysis was done inorder to determine its suitability as organic fertilizer, source of energy and as animal feed. This will provide a reasonable economic means for this waste product in an environmentally friendly manner. The result of X-ray flourences of the Arachis hypogeal L ash haven shown a high percentage of macro_elements such as Ca, Zn Mg and Cl. Also micro elements such as Cr. Thermogravimetry result indicated massive destruction organic matter leading to low ash content, which indicate its suitability as an energy source. Green house experiment was conducted on radish plant with application of the ash as a control. The yiel and yield parameters indicated high performance of the ash when applied to the plants as a fertilised in an irish mosepeat medium.

Biography:

We will update soon.

Abstract:

The research area was in Gashua, Bade Local Government Area, Yobe State, Nigeria. The levels of fluoride, cadmium, arsenic, lead, iron and nickel were determined in sachet and borehole water samples. The levels of fluoride, cadmium, arsenic, lead, iron and nickel were also determined in blood and urine samples with respect to age groups and gender. Sample collection and preparations were carried out using standard procedures. The concentrations of all the studied metals were determined using atomic absorption spectroscopy (A.A.S). The concentration of fluoride was observed to be higher in the male subjects when compared to the female subjects. It was also observed that the concentration of fluoride was significantly higher in the urine samples when compared to the blood samples. From the present study the concentration of iron ranged from 0.11 to 2.13 mg/L, 0.01 to 1.42 mg/L arsenic, 0.01 to 2.13 mg/L cadmium, 0.01 to 1.77 mg/L nickel and   0.02 to 2.13 mg/L lead. Results from the present study showed that the mean concentrations of arsenic in the borehole water samples from the different wards in Gashua ranged from 0.87 to 2.98 mg/L; 0.44 to 0.77 mg/L lead, 1.04 to 2.13 mg/L nickel, 0.12 to 0.35 mg/L cadmium and 2.56 to 5.56 mg/L iron. The values obtained from the borehole water samples were higher than the WHO standard value of 0.05 mg/L arsenic, 1.0 mg/L iron, 0.01 mg/L lead, 0.07 mg/L nickel and 0.005 mg/L cadmium for drinking water. Information from this research showed the possible factors that may result in gender metal accumulation. The concentrations of all the study metals in the urine and blood samples were significantly higher than the WHO limits. Data obtained from borehole water samples showed that, the borehole water might be a contributing factor to blood/urine metal accumulation. Information from this research also showed the possible factors that may result to higher concentrations of all the metals in urine (both recent and past exposure) when compared to blood (only recent exposure). Data obtained from the present research indicate that the concentrations of all the metals in the blood and urine samples increased with increase in age group. This fact could be explained by the tendency of heavy metals to accumulate in the human body (bioaccumulation of heavy metals) with time, indicating that metal accumulation is age dependent.